Desmoplastic Melanoma With Sarcomatoid Dedifferentiation

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Desmoplastic Melanoma

Desmoplastic melanoma is a rare variant of spindle cell melanoma that was first described in 1971 by Conley et al. [1] . Between 1988 and 2006, less than 2,000 patients were diagnosed with desmoplastic melanoma in the United States. It accounts for between 1 to 4 percent of all cases of cutaneous melanomas. [2] Early diagnosis of desmoplastic melanoma can often result in favorable outcomes due ...

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Desmoplastic Melanoma

Conley et al., in 1971, described a special type of melanoma characterized by a superficial melanic lesion at the onset; repeated local relapses as subcutaneous tumorations with an histological picture closely resembling an atypical fibroxantoma or fibrosarcoma. After a review of all the published material the autors presents a personal case with the clinical, histological and evolutive charact...

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Orbital involvement with desmoplastic melanoma.

A 79-year-old woman developed an orbital mass five and a half years after excision of a cutaneous melanoma from the side of the nose. The initial orbital biopsy was interpreted histopathologically as a malignant fibrous histiocytoma, but special stains and electron microscopy showed it to be a desmoplastic malignant melanoma which had apparently spread to the orbit from the prior skin lesion by...

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Diagnostic Challenge of Desmoplastic Melanoma

Desmoplastic melanoma (DM) is a rare variant of spindle-cell malignant melanoma. DM is easily misdiagnosed at an early stage because it can be confused with benign entities. Histological analysis, including careful attention to the presence of atypical spindle cells, as well as to lymphocytic aggregates in an abundant fibrotic stroma in the dermis, provides clues for diagnosis. The adjunction o...

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Wide excision without radiation for desmoplastic melanoma.

BACKGROUND Adjuvant radiation has been proposed for the treatment of patients with desmoplastic melanoma, who reportedly have local recurrence rates as high as 40-60%. The authors investigated local recurrence rates at a tertiary referral center to determine the success of wide excision alone for patients with desmoplastic melanoma. METHODS A review of a prospectively maintained melanoma clin...

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ژورنال

عنوان ژورنال: American Journal of Surgical Pathology

سال: 2014

ISSN: 0147-5185

DOI: 10.1097/pas.0000000000000201